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Eficacia de los AINEs en dolor articular en pollos mediante nocicepción termal

REVISTA

Descripción: Buena relación entre nocicepción termal y dolor articular tratado con AINEs en pollos

TITULO FUENTE ORIGINAL:

Thermal nociception as a measure of non-steroidal anti-inflammatory drug effectiveness in broiler chickens with articular pain.
AUTORES:

Caplen G, Baker L, Hothersall B, McKeegan DE, Sandilands V, Sparks NH, Waterman-Pearson AE, Murrell JC.
REVISTA ABREV.:

Vet J.
AÑO:

2013
REFERENCIA:

Dec;198(3):616-9.
DOI:

10.1016/j.tvjl.2013.09.013.
ENLACE:

http://www.ncbi.nlm.nih.gov/pubmed/24129110

FECHA DE PUBLICACIÓN:

01/12/2013
RESUMEN ORIGINAL:

Pain associated with poultry lameness is poorly understood. The anti-nociceptive properties of two non-steroidal anti-inflammatory drugs (NSAIDs) were evaluated using threshold testing in combination with an acute inflammatory arthropathy model. Broilers were tested in six groups (n=8 per group). Each group underwent a treatment (saline, meloxicam (3 or 5mg/kg) or carprofen (15 or... + Leer más

Pain associated with poultry lameness is poorly understood. The anti-nociceptive properties of two non-steroidal anti-inflammatory drugs (NSAIDs) were evaluated using threshold testing in combination with an acute inflammatory arthropathy model.

Broilers were tested in six groups (n=8 per group). Each group underwent a treatment (saline, meloxicam (3 or 5mg/kg) or carprofen (15 or 25mg/kg)) and a procedure (Induced (arthropathy-induction) or sham (sham-handling)) prior to testing. Induced groups had Freund's complete adjuvant injected intra-articularly into the left intertarsal joint (hock). A ramped thermal stimulus (1°C/s) was applied to the skin of the left metatarsal. Data were analysed using random-intercept multi-level models.

Saline-induced birds had a significantly higher skin temperature (± SD) than saline-sham birds (37.6±0.8°C vs. 36.5±0.5°C; Z=-3.47, P<0.001), consistent with an inflammatory response. Saline was associated with significantly lower thermal thresholds (TT) than analgesic treatment (meloxicam: Z=2.72, P=0.007; carprofen: Z=2.58, P=0.010) in induced birds. Saline-induced birds also had significantly lower TT than saline-sham birds (Z=-2.17, P=0.030).

This study found direct evidence of an association between inflammatory arthropathies and thermal hyperalgesia, and showed that NSAID treatment maintained baseline thermal sensitivity (via anti-nociception). Quantification of nociceptive responsiveness in a predictable broiler pain model identified thermal anti-hyperalgesic properties of two NSAIDs, which suggested that therapeutically effective treatment was provided at the doses administered. Such validation of analgesic strategies will increase the understanding of pain associated with specific natural broiler lameness types.

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