Activación directa de nociceptores por las bacterias

Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviours. Bacterial infections produce pain by unknown molecular mechanisms, although they are presumed to be secondary to immune activation. Here we demonstrate that bacteria directly activate nociceptors, and that the... + Leer más

Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviours. Bacterial infections produce pain by unknown molecular mechanisms, although they are presumed to be secondary to immune activation. Here we demonstrate that bacteria directly activate nociceptors, and that the immune response mediated through TLR2, MyD88, T cells, B cells, and neutrophils and monocytes is not necessary for Staphylococcus aureus-induced pain in mice. Mechanical and thermal hyperalgesia in mice is correlated with live bacterial load rather than tissue swelling or immune activation. Bacteria induce calcium flux and action potentials in nociceptor neurons, in part via bacterial N-formylated peptides and the pore-forming toxin α-haemolysin, through distinct mechanisms. Specific ablation of Nav1.8-lineage neurons, which include nociceptors, abrogated pain during bacterial infection, but concurrently increased local immune infiltration and lymphadenopathy of the draining lymph node. Thus, bacterial pathogens produce pain by directly activating sensory neurons that modulate inflammation, an unsuspected role for the nervous system in host-pathogen interactions.

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Las infecciones producen dolor por mecanismos desconocidos pero se consideraba que era por la activación de fenómenos inflamatorios. En este artículo se demuestra que las bacterias son capaces de activar directamente los nociceptores. Estos hallazgos corroboran aún más la idea de proporcionar cobertura analgésica a los pacientes que padecen infecciones... + Leer más

Las infecciones producen dolor por mecanismos desconocidos pero se consideraba que era por la activación de fenómenos inflamatorios. En este artículo se demuestra que las bacterias son capaces de activar directamente los nociceptores. Estos hallazgos corroboran aún más la idea de proporcionar cobertura analgésica a los pacientes que padecen infecciones localizadas o sistémicas.

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