REVISTA

Dexmedetomidina con butorfanol y tiletamina-zolazepam o tramadol y ketamina en perros

Valoración Valoración: 3 Estrellas

Descripción: Comparación de dos protocolos anestésicos diferentes con dexmedetomidina en perros

TITULO FUENTE ORIGINAL:

Evaluation of anesthetic, analgesic, and cardiorespiratory effects in dogs after intramuscular administration of dexmedetomidine-butorphanol-tiletamine-zolazepam or dexmedetomidine-tramadol-ketamine drug combinations

AUTORES:

Krimins RA, Ko JC, Weil AB, Payton ME

REVISTA ABREV.:

Am J Vet Res

AÑO:

2012

REFERENCIA:

73(11):1707-14

RESUMEN ORIGINAL:

OBJECTIVE:To compare anesthetic, analgesic, and cardiorespiratory effects in dogs after IM administration of dexmedetomidine (7.5 μg/kg)-butorphanol (0.15 mg/kg)-tiletamine-zolazepam (3.0 mg/kg; DBTZ) or dexmedetomidine (15.0 μg/kg)-tramadol (3.0 mg/kg)-ketamine (3.0 mg/kg; DTrK) combinations. ANIMALS:6 healthy adult mixed-breed... + Leer más

OBJECTIVE:To compare anesthetic, analgesic, and cardiorespiratory effects in dogs after IM administration of dexmedetomidine (7.5 μg/kg)-butorphanol (0.15 mg/kg)-tiletamine-zolazepam (3.0 mg/kg; DBTZ) or dexmedetomidine (15.0 μg/kg)-tramadol (3.0 mg/kg)-ketamine (3.0 mg/kg; DTrK) combinations.

ANIMALS:6 healthy adult mixed-breed dogs.

PROCEDURES:Each dog received DBTZ and DTrK in a randomized, crossover-design study with a 5-day interval between treatments. Cardiorespiratory variables and duration and quality of sedation-anesthesia (assessed via auditory stimulation and sedation-anesthesia scoring) and analgesia (assessed via algometry and electrical nerve stimulation) were evaluated at predetermined intervals.

RESULTS:DBTZ or DTrK induced general anesthesia sufficient for endotracheal intubation ≤ 7 minutes after injection. Anesthetic quality and time from drug administration to standing recovery (131.5 vs 109.5 minutes after injection of DBTZ and DTrK, respectively) were similar between treatments. Duration of analgesia was significantly longer with DBTZ treatment, compared with DTrK treatment. Analgesic effects were significantly greater with DBTZ treatment than with DTrK treatment at several time points. Transient hypertension (mean arterial blood pressure > 135 mm Hg), bradycardia (heart rate < 60 beats/min), and hypoxemia (oxygen saturation < 90% via pulse oximetry) were detected during both treatments. Tidal volume decreased significantly from baseline with both treatments and was significantly lower after DBTZ administration, compared with DTrK, at several time points.

CONCLUSIONS AND CLINICAL RELEVANCE: DBTZ or DTrK rapidly induced short-term anesthesia and analgesia in healthydogs. Further research is needed to assess efficacy of these drug combinations for surgical anesthesia. Supplemental 100% oxygen should be provided when DBTZ or DTrK are used.

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COMENTARIO DE Ignacio, Álvarez Gómez de Segura

Este estudio clinico prospectivo valora la eficacia de una técnica de analgesia locoregional tan sencilla de realizar, segura y barata como es la administración de lidocaina intratesticular en perros sometidos a orquiectomia. Emplearon 42 perros de diefernetes razas, pesos y edades que iban a ser sometidos a una castración voluntaria. Los perros se premedicaban con... + Leer más

Este estudio clinico prospectivo valora la eficacia de una técnica de analgesia locoregional tan sencilla de realizar, segura y barata como es la administración de lidocaina intratesticular en perros sometidos a orquiectomia. Emplearon 42 perros de diefernetes razas, pesos y edades que iban a ser sometidos a una castración voluntaria. Los perros se premedicaban con acepromacina y morfina, eran inducidos con porpofol y mantenidos con anestesia inhalatoria con isofluorano. En el grupo de analgésicos se administraba 2 mg/kg de lidocaina al 2% intratesticular antes de la cirugia mientras que el grupo control recibía el mismo volumen de salino. Para valorar su eficacia monitorizaban los cambios cardiorespiratorios (frecuencia cardiaca y respiratoria o presión arterial ), la presencia de movimiento o el uso de analgesia de rescate.Los perros que llevaban lidocaina experimentaron menores cambios en la frecuencia cardiaca y/o presión arterial durante la cirugía y especialmente durante la incición en piel, la exteriorización del primer testiculo y le clampaje de los conductos espermáticos. Por lo tanto, sería recomendable implementar esta técnica analgésica en nuestro protocolos anestésicos para la realización de orquiectomias.

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