La lidocaína, la dexmedetomidina y su combinación reducen la concentración alveolar mínima de isoflurano en perros

REVISTA

Descripción: La lidocaína, la dexmedetomidina y su combinación, en bolo y despues en CRI, reducen la concentración alveolar mínima de isoflurano en perro. La combinación de ambos la redujo más que empleados por separado

TITULO FUENTE ORIGINAL:

Lidocaine, dexmedetomidine and their combination reduce isoflurane minimum alveolar concentration in dogs

AUTORES:

Acevedo-Arcique CM, Ibancovichi JA, Chavez JR, Gutierrez-Blanco E, Moran-Muñoz R, Victoria-Mora JM, Tendillo-Cortijo F, Santos-González M, Sanchez-Aparicio P

REVISTA ABREV.:

Plos one

AÑO:

2014

REFERENCIA:

9(9):e106620

DOI:

10.1371/journal.pone.0106620

RESUMEN ORIGINAL:

The effects of intravenous (i.v.) lidocaine, dexmedetomidine and their combination delivered as a bolus followed by a constant rate infusion (CRI) on the minimum alveolar concentration of isoflurane (MACISO) in dogs were evaluated. Seven healthy adult dogs were included. Anaesthesia was induced with propofol and maintained with isoflurane. For each dog, baseline MAC (MACISO/BASAL) was... + Leer más

The effects of intravenous (i.v.) lidocaine, dexmedetomidine and their combination delivered as a bolus followed by a constant rate infusion (CRI) on the minimum alveolar concentration of isoflurane (MACISO) in dogs were evaluated. Seven healthy adult dogs were included. Anaesthesia was induced with propofol and maintained with isoflurane. For each dog, baseline MAC (MACISO/BASAL) was determined after a 90-minute equilibration period. Thereafter, each dog received one of the following treatments (loading dose, CRI): lidocaine 2 mg kg(-1), 100 µg kg(-1) minute(-1); dexmedetomidine 2 µg kg(-1), 2 µg kg(-1) hour(-1); or their combination. MAC was then determined again after 45- minutes of treatment by CRI. At the doses administered, lidocaine, dexmedetomidine and their combination significantly reduced MACISO by 27.3% (range: 12.5-39.2%), 43.4% (33.3-53.3%) and 60.9% (46.1-78.1%), respectively, when compared to MACISO/BASAL. The combination resulted in a greater MACISO reduction than the two drugs alone. Their use, at the doses studied, provides a clinically important reduction in the concentration of ISO during anaesthesia in dogs

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Enlace al pdf de acceso libre: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC[...]