REVISTA

Efectos fisiológicos y analgésicos de la infusión a velocidad continua de morfina, butorfanol, tramadol o metadona en caballos con sinovitis carpiana

Descripción: Efectos fisiológicos y analgésicos de la infusión a velocidad continua de morfina, butorfanol, tramadol o metadona en caballos con sinovitis carpiana inducida por lipopolisacárido (LPS)

TITULO FUENTE ORIGINAL:

Physiological and analgesic effects of continuous-rate infusion of morphine, butorphanol, tramadol or methadone in horses with lipopolysaccharide (LPS)-induced carpal synovitis

AUTORES:

Adriano B Carregaro,corresponding author Gabrielle C Freitas, Martina H Ribeiro, Nathalia V Xavier, and Renata GS Dória

REVISTA ABREV.:

BMC Veterinary Research

AÑO:

2014

REFERENCIA:

10: 966

DOI:

10.1186/s12917-014-0299-z

RESUMEN ORIGINAL:

Background
Continuous-rate infusion (CRI) of drugs results in more stable plasma drug concentrations than administration of intermittent boluses, thus providing greater stability of physiological parameters. The aim of this study was to evaluate the physiologic and analgesic effects of the administration of morphine, butorphanol, tramadol or methadone by CRI in horses with induced...
+ Leer más

Background
Continuous-rate infusion (CRI) of drugs results in more stable plasma drug concentrations than administration of intermittent boluses, thus providing greater stability of physiological parameters. The aim of this study was to evaluate the physiologic and analgesic effects of the administration of morphine, butorphanol, tramadol or methadone by CRI in horses with induced synovitis of the radiocarpal joint.

Results
Increased values of cardiorespiratory parameters and body temperature were observed in all groups after initiation of opioid administration, and these increases were sustained throughout the CRI period. Morphine, butorphanol and methadone each caused a reduction in gut sounds, and this effect was greatest in animals that received morphine. Administration of morphine or methadone reduced the degree of lameness after the end of intravenous infusion. Administration of tramadol did not alter the degree of lameness in the animals.

Conclusions
CRI of morphine or methadone, but not butorphanol or tramadol, provided analgesia in horses with carpal synovitis. All of these opioids increased cardiovascular and respiratory parameters and reduced gut sounds during CRI

- Leer menos

ENLACES DE INTERÉS

Enlace al pdf de acceso libre: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC[...]