REVISTA

Detección del control del dolor en gatos con enfermedad degenerativa articular

Descripción: Empleando métodos aplicados por veterinarios y propietarios puede determinarse la eficacia de la terapia analgésica

TITULO FUENTE ORIGINAL:

Detection of clinically relevant pain relief in cats with degenerative joint disease associated pain

AUTORES:

Gruen ME, Griffith E, Thomson A, Simpson W, Lascelles BD

REVISTA ABREV.:

J Vet Intern Med

AÑO:

2014

REFERENCIA:

28(2):346-50

DOI:

10.1111/jvim.12312

RESUMEN ORIGINAL:

BACKGROUND:
Detection of clinically relevant pain relief in cats with degenerative joint disease (DJD) is complicated by a lack of validated outcome measures and a placebo effect.
HYPOTHESIS/OBJECTIVES:
To evaluate a novel approach for detection of pain relief in cats with DJD.
ANIMALS:
Fifty-eight client-owned cats.
METHODS:
Prospective,...
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BACKGROUND:
Detection of clinically relevant pain relief in cats with degenerative joint disease (DJD) is complicated by a lack of validated outcome measures and a placebo effect.

HYPOTHESIS/OBJECTIVES:
To evaluate a novel approach for detection of pain relief in cats with DJD.

ANIMALS:
Fifty-eight client-owned cats.

METHODS:
Prospective, double-masked, placebo-controlled, stratified, randomized, clinical study. Enrolled cats were 6-21 years of age, with owner-observed mobility impairment, evidence of pain in at least 2 joints during orthopedic examination, and overlapping radiographic evidence of DJD, and underwent a 2-week baseline period, 3-week treatment period with placebo or meloxicam, and 3-week masked washout period. Outcome measures were evaluated at days 0, 15, 36, and 57.

RESULTS:
Both groups significantly improved after the treatment period (day 36) on client-specific outcome measures (CSOM) and feline musculoskeletal pain index (FMPI) (P < .0001 for both); there was no difference between the groups on CSOM or FMPI score improvement. After the masked washout period, more cats that received meloxicam during the treatment period had a clinically relevant decrease in CSOM score (P = .048) and FMPI score (P = .021) than cats that received placebo.

CONCLUSIONS AND CLINICAL IMPORTANCE:
Using both a client-specific and a general clinical metrology instrument, owners of cats with DJD were able to detect evident recurrence of clinical signs after withdrawal of active medication than after withdrawal of placebo, and that this study design might be a novel and useful way to circumvent the placebo effect and detect the efficacy of pain-relieving medications.

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ENLACES DE INTERÉS

Enlace al texto de acceso libre:: https://onlinelibrary.wiley.com/doi/full/10.1[...]

Enlace al pdf de acceso libre:: https://onlinelibrary.wiley.com/doi/epdf/10.1[...]