REVISTA

Objetivos emergentes en el dolor crónico neuroinflamatorio

Descripción: Nuevos planteamientos terapéuticos para el tratamiento del dolor crónico neuroinflamatorio

TITULO FUENTE ORIGINAL:

Emerging targets in neuroinflammation-driven chronic pain

AUTORES:

Ji RR, Xu ZZ, Gao YJ

REVISTA ABREV.:

Nat Rev Drug Discov

AÑO:

2014

REFERENCIA:

13(7):533-48

DOI:

10.1038/nrd4334

RESUMEN ORIGINAL:

Current analgesics predominately modulate pain transduction and transmission in neurons and have limited success in controlling disease progression. Accumulating evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of glial cells and production of inflammatory mediators in the peripheral and central nervous system, has an important role... + Leer más

Current analgesics predominately modulate pain transduction and transmission in neurons and have limited success in controlling disease progression. Accumulating evidence suggests that neuroinflammation, which is characterized by infiltration of immune cells, activation of glial cells and production of inflammatory mediators in the peripheral and central nervous system, has an important role in the induction and maintenance of chronic pain. This Review focuses on emerging targets - such as chemokines, proteases and the WNT pathway - that promote spinal cord neuroinflammation and chronic pain. It also highlights the anti-inflammatory and pro-resolution lipid mediators that act on immune cells, glial cells and neurons to resolve neuroinflammation, synaptic plasticity and pain. Targeting excessive neuroinflammation could offer new therapeutic opportunities for chronic pain and related neurological and psychiatric disorders.

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ENLACES DE INTERÉS

Enlace al pdf de acceso libre: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC[...]