REVISTA

Hiperalgesia inducida por opioides (OIH): ¿un problema clínico real o simplemente un fenómeno experimental?

Descripción: Posibles causas de la necesidad de aumentar la dosis de opiodes en pacientes con dolor cronico que han sido atribuidas a la hiperalgesia inducida por opioides (OIH)

TITULO FUENTE ORIGINAL:

Opioid-induced hyperalgesia (OIH): a real clinical problem or just an experimental phenomenon?

AUTORES:

Eisenberg E, Suzan E, Pud D

REVISTA ABREV.:

Journal of Pain and Symptom Management

AÑO:

2015

REFERENCIA:

49(3):632-6

DOI:

10.1016/j.jpainsymman.2014.07.005

RESUMEN ORIGINAL:

Although opioid-induced hyperalgesia (OIH) is mentioned as a potential cause of opioid dose escalation without adequate analgesia, true evidence in support of this notion is relatively limited. Most studies conducted in the context of acute and experimental pain, which seemingly demonstrated evidence for OIH, actually might have measured other phenomena such as acute opioid withdrawal or... + Leer más

Although opioid-induced hyperalgesia (OIH) is mentioned as a potential cause of opioid dose escalation without adequate analgesia, true evidence in support of this notion is relatively limited. Most studies conducted in the context of acute and experimental pain, which seemingly demonstrated evidence for OIH, actually might have measured other phenomena such as acute opioid withdrawal or tolerance. OIH studies in patients with chronic pain have used various experimental pain models (such as cold pain tolerance or heat pain intensity). Therefore, the fact that they have yielded inconsistent results is hard to interpret. Thus far, with the exception of a few clinical case reports on OIH in patients with cancer pain and one prospective study in patients with chronic neuropathic pain, evidence for OIH in patients with chronic or cancer-related pain is lacking. Whether experimental pain models are necessary for establishing the clinical diagnosis of OIH, and which specific model is preferred, are yet to be determined

- Leer menos

ENLACES DE INTERÉS

Enlace al pdf de acceso libre: https://www.jpsmjournal.com/article/S0885-392[...]