REVISTA

[(18) F] tomografía por emisión de positrones con fluorodesoxiglucosa del cerebro del gato: un estudio de viabilidad para investigar el dolor asociado

Descripción: [(18) F] tomografía por emisión de positrones con fluorodesoxiglucosa del cerebro del gato: un estudio de viabilidad para investigar el dolor asociado a la osteoartritis

TITULO FUENTE ORIGINAL:

[(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

AUTORES:

Guillot M, Chartrand G, Chav R, Rousseau J, Beaudoin JF, Martel-Pelletier J, Pelletier JP, Lecomte R, de Guise JA, Troncy E

REVISTA ABREV.:

The veterinary journal

AÑO:

2015

REFERENCIA:

204(3):299-303

DOI:

10.1016/j.tvjl.2015.03.023

RESUMEN ORIGINAL:

The objective of this pilot study was to investigate central nervous system (CNS) changes related to osteoarthritis (OA)-associated chronic pain in cats using [(18)F]-fluorodeoxyglucose ((18)FDG) positron emission tomography (PET) imaging. The brains of five normal, healthy (non-OA) cats and seven cats with pain associated with naturally occurring OA were imaged using (18)FDG-PET during a... + Leer más

The objective of this pilot study was to investigate central nervous system (CNS) changes related to osteoarthritis (OA)-associated chronic pain in cats using [(18)F]-fluorodeoxyglucose ((18)FDG) positron emission tomography (PET) imaging. The brains of five normal, healthy (non-OA) cats and seven cats with pain associated with naturally occurring OA were imaged using (18)FDG-PET during a standardized mild anesthesia protocol. The PET images were co-registered over a magnetic resonance image of a cat brain segmented into several regions of interest. Brain metabolism was assessed in these regions using standardized uptake values. The brain metabolism in the secondary somatosensory cortex, thalamus and periaqueductal gray matter was increased significantly (P ≤ 0.005) in OA cats compared with non-OA cats. This study indicates that (18)FDG-PET brain imaging in cats is feasible to investigate CNS changes related to chronic pain. The results also suggest that OA is associated with sustained nociceptive inputs and increased activity of the descending modulatory pathways

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