REVISTA

Diferentes células inmunes median la hipersensibilidad mecánica al dolor en ratones machos y hembras

Descripción: Diferentes células inmunes median la hipersensibilidad mecánica al dolor cronico en ratones machos y hembras

TITULO FUENTE ORIGINAL:

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

AUTORES:

Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS

REVISTA ABREV.:

Nature

AÑO:

2015

REFERENCIA:

18(8):1081-3

DOI:

10.1038/nn.4053

RESUMEN ORIGINAL:

A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism... + Leer más

A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research

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ENLACES DE INTERÉS

Enlace al pdf de acceso libre: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC[...]