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Propiedades farmacocinéticas de una administración única de gabapentina oral en Bubo virginianus

Valoración: 4 Estrellas
REVISTA

Descripción: Farmacocinética de la administración única de gabapentina durante 48 horas en Bubo virginianus

TITULO FUENTE ORIGINAL:

PHARMACOKINETIC PROPERTIES OF A SINGLE ADMINISTRATION OF ORAL GABAPENTIN IN THE GREAT HORNED OWL (BUBO VIRGINIANUS)
AUTORES:

Yaw TJ, Zaffarano BA, Gall A, Olds JE, Wulf L, Papastavros E, Coetzee JF.
REVISTA ABREV.:

J Zoo Wildl Med.
AÑO:

2015
REFERENCIA:

Sep;46(3):547-52
DOI:

10.1638/2015-0018.1
ENLACE:

http://www.ncbi.nlm.nih.gov/pubmed/26352959

FECHA DE PUBLICACIÓN:

01/09/2015
RESUMEN ORIGINAL:

Abstract
Gabapentin (1-[aminomethyl] cyclohexane acetic acid) is a γ-aminobutyric acid analogue that has been shown to be efficacious for neuropathic pain control in humans. Plasma gabapentin concentrations >2 μg/ml are considered effective in treating epilepsy in humans and are suggested to provide analgesia for neuropathic pain. This study investigated the pharmacokinetics... + Leer más

Abstract
Gabapentin (1-[aminomethyl] cyclohexane acetic acid) is a γ-aminobutyric acid analogue that has been shown to be efficacious for neuropathic pain control in humans. Plasma gabapentin concentrations >2 μg/ml are considered effective in treating epilepsy in humans and are suggested to provide analgesia for neuropathic pain. This study investigated the pharmacokinetics of a single oral dose of gabapentin suspension (11 mg/kg) in great horned owls ( Bubo virginianus ). Plasma gabapentin concentrations were determined in six healthy birds for 48 hr using high-performance liquid chromatography with mass spectrometric detection. Plasma gabapentin concentrations were estimated by noncompartmental pharmacokinetic analysis. The harmonic mean (±SD) maximum concentration (Cmax), time to maximum concentration (Tmax), and elimination half-life (tv2λZ) for gabapentin (11 mg/kg) were 6.17±0.83 μg/ml, 51.43±5.66 min, and 264.60±69.35 min, respectively. In this study, plasma gabapentin concentrations were maintained above 2 μg/ml for 528 min (8.8 hr), suggesting that gabapentin administered orally every 8 hr may be appropriate in great horned owls.

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