REVISTA

Precursores de interneuronas derivadas de células madre humanas trasplantadas mitigan la disfunción de la vejiga del ratón y el dolor neuropático cent

Descripción: Precursores de interneuronas derivadas de células madre humanas trasplantadas mitigan la disfunción de la vejiga del ratón y el dolor neuropático central después de una lesión de la médula espinal

TITULO FUENTE ORIGINAL:

Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury

AUTORES:

Fandel TM, Trivedi A, Nicholas CR, Zhang H, Chen J, Martinez AF, Noble-Haeusslein LJ, Kriegstein AR

REVISTA ABREV.:

Cell Stem Cell

AÑO:

2016

REFERENCIA:

19(4):544-557

DOI:

10.1016/j.stem.2016.08.020

RESUMEN ORIGINAL:

Neuropathic pain and bladder dysfunction represent significant quality-of-life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to the emergence of these symptoms. Previous studies have shown that transplantation of rodent inhibitory interneuron precursors from the medial ganglionic eminence (MGE) enhances GABAergic signaling in the... + Leer más

Neuropathic pain and bladder dysfunction represent significant quality-of-life issues for many spinal cord injury patients. Loss of GABAergic tone in the injured spinal cord may contribute to the emergence of these symptoms. Previous studies have shown that transplantation of rodent inhibitory interneuron precursors from the medial ganglionic eminence (MGE) enhances GABAergic signaling in the brain and spinal cord. Here we look at whether transplanted MGE-like cells derived from human embryonic stem cells (hESC-MGEs) can mitigate the pathological effects of spinal cord injury. We find that 6 months after transplantation into injured mouse spinal cords, hESC-MGEs differentiate into GABAergic neuron subtypes and receive synaptic inputs, suggesting functional integration into host spinal cord. Moreover, the transplanted animals show improved bladder function and mitigation of pain-related symptoms. Our results therefore suggest that this approach may be a valuable strategy for ameliorating the adverse effects of spinal cord injury

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ENLACES DE INTERÉS

Enlace al pdf de acceso libre: https://www.cell.com/action/showPdf?pii=S1934[...]