TITULO FUENTE ORIGINAL: Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain. |
AUTORES: Kistner K, Siklosi N, Babes A, Khalil M, Selescu T, Zimmermann K, Wirtz S, Becker C, Neurath MF, Reeh PW, Engel MA |
REVISTA ABREV.: Sci Rep |
AÑO: 2016 |
REFERENCIA: 6:28621 |
DOI: 10.1038/srep28621 |
RESUMEN ORIGINAL:
We demonstrate a novel dual strategy against inflammation and pain through body-wide desensitization of nociceptors via TRPA1. Attenuation of experimental colitis by capsazepine (CPZ) has long been attributed to its antagonistic action on TRPV1 and associated inhibition of neurogenic inflammation. In contrast, we found that CPZ exerts its anti-inflammatory effects via profound desensitization... + Leer más |
ENLACES DE INTERÉS Descarga gratuita PDF: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4[...] Web del contenido: http://www.nature.com/articles/srep28621 |