TITULO FUENTE ORIGINAL: Central mechanisms of pathological pain |
AUTORES: Kuner R |
REVISTA ABREV.: Nat Med |
AÑO: 2016 |
REFERENCIA: 16(11):1258-66 |
DOI: 10.1038/nm.2231 |
RESUMEN ORIGINAL:
Chronic pain is a major challenge to clinical practice and basic science. The peripheral and central neural networks that mediate nociception show extensive plasticity in pathological disease states. Disease-induced plasticity can occur at both structural and functional levels and is manifest as changes in individual molecules, synapses, cellular function and network activity. Recent work has... + Leer más |