TITULO FUENTE ORIGINAL: Structure-based discovery of opioid analgesics with reduced side effects |
AUTORES: Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK |
REVISTA ABREV.: Nature |
AÑO: 2016 |
REFERENCIA: 1-6 |
DOI: 10.1038/nature19112 |
RESUMEN ORIGINAL:
Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side effects of morphine and related opioids-which include fatal respiratory depression-are thought to be mediated by μ-opioid-receptor (μOR) signalling through the β-arrestin pathway or by actions at other receptors. Conversely, G-protein μOR signalling is thought to confer analgesia. Here we... + Leer más |