TITULO FUENTE ORIGINAL: Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs |
AUTORES: Messenger KM, Hopfensperger M, Knych HK, Papich MG |
REVISTA ABREV.: Am J Vet Res |
AÑO: 2016 |
REFERENCIA: 77(4):413-20 |
DOI: 10.2460/ajvr.77.4.413 |
RESUMEN ORIGINAL:
OBJECTIVE To determine the pharmacokinetics of detomidine hydrochloride administered IV (as an injectable formulation) or by the oral-transmucosal (OTM) route (as a gel) and assess sedative effects of the OTM treatment in healthy dogs. ANIMALS 12 healthy adult dogs. PROCEDURES In phase 1, detomidine was administered by IV (0.5 mg/m(2)) or OTM (1 mg/m(2)) routes to 6 dogs. After a 24-hour... + Leer más |
COMENTARIO
En este estudio no se valora el dolor, pero dados los efectos analgésicos de la medetomidina, la sedación empleando esta vía transmucosa puede ser útil para ciertos procedimientos dolorosos leves o como analgesia complementaria. |