TITULO FUENTE ORIGINAL: Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain — In vivo and in vitro evidence |
AUTORES: Piotrowskaa A., Kwiatkowskia K., Rojewskaa E., Slusarczykb J., Makucha W., Basta-Kaimb A., Przewlockaa B., Mikaa J. |
REVISTA ABREV.: J Neuroimmunol |
AÑO: 2016 |
REFERENCIA: 297:9-19 |
DOI: 10.1016/j.jneuroim.2016.04.017 |
RESUMEN ORIGINAL:
The repeated administration of microglial inhibitor (minocycline) and CCR2 antagonist (RS504393) attenuated the neuropathic pain symptoms in rats following chronic constriction injury of the sciatic nerve, which was associated with decreased spinal microglia activation and the protein level of CCL2 and CCR2. Furthermore, in microglia primary cell cultures minocycline downregulated both CCL2... + Leer más |