REVISTA

Derivados furano-diterpeno del género Pterodon genus: los estudios farmacológicos revelan su potencial como alivio del dolor crónico en ratones

Descripción: Los furano-diterpenos que posee el esqueleto de vouacapan, aislado del género Pterodon, poseen actividad antinociceptiva y también son eficaces para disminuir la alodinia mecánica, esto postula un uso potencial como tratamiento del dolor crónico

TITULO FUENTE ORIGINAL:

Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice

AUTORES:

Humberto M Spindola, Rogério Grando, Mariana C Figueiredo, Rosana Basting, N C A Queiroz, Ângelo de Fátima, João E de Carvalho, Zaijie J Wang, M A Foglio

REVISTA ABREV.:

Eur J Pharmacol

AÑO:

2017

REFERENCIA:

804:68-77

DOI:

10.1016/j.ejphar.2017.03.030

RESUMEN ORIGINAL:

Pterodon genus fruits are commercially available at the Brazilian medicinal market used in folk medicine due to their anti-inflammatory, analgesic, and anti-rheumatic effects. Previous studies demonstrated that furanditerpenes possessing vouacapan skeleton, isolated from Pterodon genus, possess expressive antinociceptive activities, with promising moiety for the development of new analgesic... + Leer más

Pterodon genus fruits are commercially available at the Brazilian medicinal market used in folk medicine due to their anti-inflammatory, analgesic, and anti-rheumatic effects. Previous studies demonstrated that furanditerpenes possessing vouacapan skeleton, isolated from Pterodon genus, possess expressive antinociceptive activities, with promising moiety for the development of new analgesic products. The antinociceptive properties of compounds 6α,7β-6α-hidroxivouacapan-7β-17β-lactone (HVL) and 6α-oxovouacapan-7β-17β-lactone (OVL), semi-synthetic analogues of furanditerpenes previously reported as analgesic agents were evaluated on animal experimental models (Spindola et al., 2010, 2011). The chemical-induced pain methods used in the present work, demonstrated for the first time that both compounds HVL and OVL have potential as important templates for the development of chronic pain control drugs. The main findings of this work were that both compounds were: effective in the writhing test; reduced paw edema in the carrageenan test; effective in the inflammatory phase of the formalin test corroborating their activity against inflammatory pain conditions; effective on reducing pain through the stimulation of vanilloid receptors sensible to capsaicin (an important pathway for chronic pain maintenance); reduced the pain stimulus caused by PGE2 injection (a pathway involved in chronic pain hypersensitivity); effective on decreasing mechanical allodynia in the CFA-model, demonstrating their potential use against chronic pain disorders

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