REVISTA

Farmacogenética de analgésicos opioides en perros

Descripción: Esta revisión analiza el metabolismo de los fármacos opioides y el posible polimorfismo genético de las enzimas metabolizadoras en perros

TITULO FUENTE ORIGINAL:

Pharmacogenetics of opioid analgesics in dogs

AUTORES:

Kongara K

REVISTA ABREV.:

J Vet Pharmacol Ther

AÑO:

2018

REFERENCIA:

41(2):195-204

DOI:

10.1111/jvp.12452

RESUMEN ORIGINAL:

Genetic variation causes interindividual variability in drug absorption, distribution, metabolism and excretion. These pharmacokinetic processes will influence the observed efficacy and toxicity of a drug. Polymorphisms in the genes encoding the metabolizing enzymes, transport proteins and receptors have been linked to the inconsistency in responses to opioid treatment in humans and laboratory... + Leer más

Genetic variation causes interindividual variability in drug absorption, distribution, metabolism and excretion. These pharmacokinetic processes will influence the observed efficacy and toxicity of a drug. Polymorphisms in the genes encoding the metabolizing enzymes, transport proteins and receptors have been linked to the inconsistency in responses to opioid treatment in humans and laboratory animals. Pharmacogenetics is relatively less developed field in veterinary medicine compared to significant advances in knowledge on genetic basis of variation in drug responses and clinical applications in human medicine. This review discusses the opioid drug metabolism and possible genetic polymorphism of metabolizing enzymes in dogs. Polymorphism of genes encoding opioid drug transporter proteins and its effect on opioid response and opioid receptor gene variants are also discussed. Due to the scarcity of studies reported on opioid pharmacogenetics in dogs, relevant studies in humans and rodents have also been discussed to indicate current trends and potential targets for research in dogs

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