REVISTA

¿Podría la epigenética ayudar a explicar las disparidades raciales en el dolor crónico?

Descripción: Los cambios de metilación del ADN pueden desempeñar un papel esencial en la modulación epigenética del dolor crónico en diferentes razas con una mayor incidencia de alteraciones epigenéticas que contribuyen a un dolor crónico más severo e incapacitante en los afroamericanos

TITULO FUENTE ORIGINAL:

Could epigenetics help explain racial disparities in chronic pain?

AUTORES:

Edwin N Aroke, Paule V Joseph, Abhrarup Roy, Demario S Overstreet, Trygve O Tollefsbol, David E Vance, Burel R Goodin

REVISTA ABREV.:

J Pain Res

AÑO:

2019

REFERENCIA:

12:701-710

DOI:

10.2147/JPR.S191848

RESUMEN ORIGINAL:

African Americans disproportionately suffer more severe and debilitating morbidity from chronic pain than do non-Hispanic Whites. These differences may arise from differential exposure to psychosocial and environmental factors such as adverse childhood experiences, racial discrimination, low socioeconomic status, and depression, all of which have been associated with chronic stress and chronic... + Leer más

African Americans disproportionately suffer more severe and debilitating morbidity from chronic pain than do non-Hispanic Whites. These differences may arise from differential exposure to psychosocial and environmental factors such as adverse childhood experiences, racial discrimination, low socioeconomic status, and depression, all of which have been associated with chronic stress and chronic pain. Race, as a social construct, makes it such that African Americans are more likely to experience different early life conditions, which may induce epigenetic changes that sustain racial differences in chronic pain. Epigenetics is one mechanism by which environmental factors such as childhood stress, racial discrimination, economic hardship, and depression can affect gene expression without altering the underlying genetic sequence. This article provides a narrative review of the literature on epigenetics as a mechanism by which differential environmental exposure could explain racial differences in chronic pain. Most studies of epigenetic changes in chronic pain examine DNA methylation. DNA methylation is altered in the glucocorticoid (stress response) receptor gene, NR3C1, which has been associated with depression, childhood stress, low socioeconomic status, and chronic pain. Similarly, DNA methylation patterns of immune cytokine genes have been associated with chronic stress states. Thus, DNA methylation changes may play an essential role in the epigenetic modulation of chronic pain in different races with a higher incidence of epigenetic alterations contributing to more severe and disabling chronic pain in African Americans

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ENLACES DE INTERÉS

Enlace al pdf de acceso libre: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC[...]