REVISTA DESTACADA

Valor de las pruebas hepáticas y renales previas a un tratamiento con AINE en perros

Valoración Valoración: 4 Estrellas

Descripción: El estudio sugiere la importancia de realizar pruebas analíticas de función hepática y renal a perros de más de 8 años. Las elevaciones de niveles de enzimas hepáticas podrían tener mas relevancia que las pruebas renales.

TITULO FUENTE ORIGINAL:

Evaluation of renal and hepatic blood value screening before non‐steroidal anti‐inflammatory drug administration in dogs

AUTORES:

Chalifoux NV, Kaiman G, Drobatz KJ, Thawley VJ

REVISTA ABREV.:

J Small Anim Pract

AÑO:

2021

REFERENCIA:

62(1):12-18

DOI:

10.1111/jsap.13230

RESUMEN ORIGINAL:

Objectives: To evaluate the potential association between signalment, history and physical examination findings and elevated renal and hepatic blood values before non-steroidal anti-inflammatory drug administration in dogs. Secondary objectives were to investigate clinicopathologic differences between dogs that were and were not prescribed a non-steroidal anti-inflammatory... + Leer más

Objectives: To evaluate the potential association between signalment, history and physical examination findings and elevated renal and hepatic blood values before non-steroidal anti-inflammatory drug administration in dogs. Secondary objectives were to investigate clinicopathologic differences between dogs that were and were not prescribed a non-steroidal anti-inflammatory drug.

Materials and methods: Medical records of 81 dogs that underwent renal and hepatic blood value screening before drug administration via a non-steroidal anti-inflammatory drug blood panel were reviewed retrospectively. Patient signalment, history and physical examination findings were recorded.

Results: Six (7%) dogs had an elevated blood urea nitrogen, 2 (2%) dogs had an elevated creatinine, 24 (30%) dogs had an elevated alanine aminotransferase, 29 (36%) had an elevated aspartate aminotransferase and 14 (17%) had an elevated alkaline phosphatase. Forty-five (56%) dogs had an elevation in at least 1 renal or hepatic blood value. Dogs less than 8 years of age and with a longer duration of clinical signs were less likely to have an elevated renal or hepatic blood value. Dogs with elevated hepatic blood values were less likely to be prescribed a non-steroidal anti-inflammatory drug; however, this was not true for elevated renal parameters alone.

Clinical significance: The results of this preliminary study suggest that blood value screening before non-steroidal anti-inflammatory drug administration may be important for dogs greater than 8 years of age. Hepatic enzyme elevations may play a greater role in clinical decision making in comparison to renal parameters.

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COMENTARIO

Dada la toxicidad potencial de los tratameintos crónicos con AINE, no se han descrito que pruebas pueden ser relavantes para la evaluación del riesgo. los autores sugieren la relevancia de las pruebas hepáticas en perros de más de ocho añois de edad.

ENLACES DE INTERÉS

Enlace a la editorial: : https://onlinelibrary.wiley.com/doi/full/10.1[...]

Enlace a la editorial: : https://onlinelibrary.wiley.com/doi/full/10.1[...]